Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation
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چکیده
منابع مشابه
Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation.
CD14+ peripheral blood monocytes can differentiate into fibroblast-like cells called fibrocytes, which are associated with and are at least partially responsible for wound healing and fibrosis in multiple organ systems. Signals regulating fibrocyte differentiation are poorly understood. In this study, we find that when added to human PBMCs cultured in serum-free medium, the profibrotic cytokine...
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The description of two subtypes of T helper cells based on cytokine profiles by Mosman and Coffman in 1986 was a major step forward in thinking on control of immune responses. Building on previous divisions of responses into predominantly humoral or predominantly cellmediated, they described murine T cells clones that could be divided into either Th-1 producing IFN-y and IL-2 but not IL-4 and I...
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The mannose receptor is a macrophage surface receptor that mediates both endocytosis and phagocytosis. Previous work has demonstrated that the prototypical Th 2 cytokine, interleukin-4 (IL-4), increases both cell-surface receptor expression and mannose receptor-mediated endocytosis, whereas the prototypical Th 1 cytokine, interferon-γ (IFN-γ), decreases both surface expression and endocytosis. ...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2008
ISSN: 0741-5400
DOI: 10.1189/jlb.1107782